The mesenchymal tumor microenvironment

The Role of Mesenchymal Stem Cells in the Tumor Microenvironment

Functional subsets of mesenchymal cell types in the tumor microenvironment.

In the field of tumor biology, increasing attention is now focused on the complex interactions between various constituent cell types within the tumor microenvironment as being functionally important for the etiology of the disease. The detailed description of tumor-promoting properties of cancer-associated fibroblasts, endothelial cells, pericytes, and immune cells, introduces novel potential ...

The roles of mesenchymal stem cells in tumor inflammatory microenvironment

Tumor behavior is not entirely determined by tumor cells. Studies have demonstrated that a variety of non-tumor cells in the tumor microenvironment affect tumor behavior; thus, a new focus of cancer research has been the development of novel cancer treatment ideas and therapeutic targets based on the effects of these cells. Mesenchymal stem cells (MSCs) are an important component of the tumor m...

Tumor microenvironment and the role of mesenchymal stromal cells.

UNLABELLED Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological properties of the tumor. This minireview is focused on recent advances in the u...

Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment.

Mesenchymal stem cells (MSC) migrate to and proliferate within sites of inflammation and tumors as part of the tissue remodeling process. Radiation increases the expression of inflammatory mediators that could enhance the recruitment of MSC into the tumor microenvironment. To investigate this, bilateral murine 4T1 breast carcinomas (expressing renilla luciferase) were irradiated unilaterally (1...